LunaKIDNEY (Luna kidney)

Description of Composition:

Melatonin: A powerful antioxidant and circadian rhythm regulator, melatonin helps mitigate oxidative stress, inflammation, and mitochondrial dysfunction—all contributing factors to CKD progression.

Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus bulgaricus, Lactobacillus plantarum: These probiotics work synergistically to improve gut health, enhance immune responses, and modulate inflammation.

Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium infantis: These strains reduce pro-inflammatory cytokines, support glucose and lipid metabolism, and optimize gut health.

Streptococcus thermophilus: This probiotic strengthens gut barrier function, enhances nutrient absorption, and reduces systemic inflammation, supporting kidney and metabolic health.

Research Articles Supporting Melatonin and Gut Microbiome:

Melatonin in Kidney Diseases:
 
 Markowska M, Niemczyk S, Romejko K. Melatonin Treatment in Kidney Diseases. Cells. 2023 Mar 8;12(6):838. 
 
Probiotics and Renal Function:
  Dai Y, Quan J, Xiong L, Luo Y, Yi B. Probiotics improve renal function, glucose, lipids, inflammation, and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis. Ren Fail. 2022 Dec;44(1):862-880.

 Melatonin as an Antioxidant:
  Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre-Jimenez M, Qin L. Melatonin as an antioxidant: under promises but over delivers. J Pineal Res. 2016 Oct;61(3):253-78.

 Anti-Inflammatory Effects of Melatonin:
  Prado NJ, Ferder L, Manucha W, Diez ER. Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension. Curr Hypertens Rep. 2018 May 9;20(5):45.

 Melatonin and the Renin-Angiotensin System (RAS):
  Rahman A, Hasan AU, Kobori H. Melatonin in chronic kidney disease: a promising chronotherapy targeting the intrarenal renin-angiotensin system. Hypertens Res. 2019;42(6):920-923.

 Melatonin and CKD Risk Factors:
  Theofilis P, Vordoni A, Kalaitzidis RG. The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal?. Am J Nephrol. 2022;53(7):565-574.

Melatonin and Mitophagy in Atherosclerosis:
  Ajoolabady A, Bi Y, McClements DJ, et al. Melatonin-based therapeutics for atherosclerotic lesions and beyond: Focusing on macrophage mitophagy. Pharmacol Res. 2022;176:106072.

 Inflammasome Inhibition by Melatonin:
  Ma S, Chen J, Feng J, et al. Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition. Oxid Med Cell Longev. 2018;2018:9286458.

 Melatonin and Circadian Regulation:
  Zisapel N. New perspectives on the role of melatonin in human sleep, circadian rhythms, and their regulation. Br J Pharmacol. 2018 Aug;175(16):3190-3199.